Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13
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DOI: 10.1038/s41598-019-47034-6
Abstract: Numerous mutations in the Plasmodium falciparum Kelch13 (K13) protein confer resistance to artemisinin derivatives, the current front-line antimalarial drugs. K13 is an essential protein that contains BTB and Kelch-repeat propeller (KREP) domains usually found in… read more here.
Keywords: protein; comparative structural; k13; artemisinin resistance ... See more keywords
Structural Modelling Prediction of Recombinant Plasmodium falciparum K13-F446I and K13-C580Y Gene by AlphaFold Method and Heterologous Expression in Spodoptera frugiperda 9 Cells
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DOI: 10.3390/pathogens11111271
Abstract: P. falciparum Kelch 13 (Pfk13) is an essential protein that contains BTB and Kelch-repeat propeller domains (KRPD), which was predicted to bind substrate during ubiquitin-dependent degradation pathway. However, the function of Pfk13 and the structural… read more here.
Keywords: c580y; pfk13 f446i; protein; k13 ... See more keywords