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   Articles with "k18 hace2" as a keyword



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Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.102479

Abstract: Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that antibody treatments need to rely on highly neutralizing monoclonal antibodies (mAbs), targeting several distinct… read more here.

Keywords: spike terminal; terminal domain; k18 hace2; sars cov ... See more keywords
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The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner.

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recommendations! Published in 2023 at "British journal of pharmacology"

DOI: 10.1111/bph.16155

Abstract: BACKGROUND AND PURPOSE COVID-19 infections caused by SARS-CoV-2 disseminate through human-to-human transmission can evoke severe inflammation. Treatments to reduce the SARS-CoV-2-associated inflammation are needed and are the focus of much research. In this study, we… read more here.

Keywords: k18 hace2; infection; hace2 mice; severity ... See more keywords
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The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.00683-22

Abstract: SARS-CoV-2 variants, with the threat of increased transmissibility, infectivity, and immune escape, continue to emerge as the COVID-19 pandemic progresses. Detailing the pathogenesis of disease caused by SARS-CoV-2 variants, such as Delta, is essential to… read more here.

Keywords: cov variants; k18 hace2; delta; disease ... See more keywords
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Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model

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recommendations! Published in 2021 at "Microbiology spectrum"

DOI: 10.1128/spectrum.00536-21

Abstract: The COVID-19 pandemic has resulted in millions of deaths. The host’s respiratory and intestinal microbiome can affect directly or indirectly the immune system during viral infections. ABSTRACT Transmission of the severe acute respiratory syndrome coronavirus… read more here.

Keywords: microbiome; k18 hace2; sars cov; intestinal microbiome ... See more keywords

Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice.

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recommendations! Published in 2022 at "JCI insight"

DOI: 10.1172/jci.insight.157393

Abstract: SARS-CoV-2 has resulted in over 450 million confirmed cases since 2019. Although several vaccines have been certified by World Health Organization and are being vaccinated on a global scale, it has been reported that multiple… read more here.

Keywords: immunity; k18 hace2; sars cov; cov challenge ... See more keywords
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Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0272019

Abstract: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is currently spreading globally. To overcome the COVID-19 pandemic, preclinical evaluations of vaccines and therapeutics using K18-hACE2 and CAG-hACE2 transgenic mice are ongoing.… read more here.

Keywords: k18 hace2; hace2; cag hace2; hace2 mice ... See more keywords

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0273430

Abstract: The COVID-19 pandemic has been fueled by novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other properties that enhance disease. The goal of this study is to characterize unique pathogenesis… read more here.

Keywords: k18 hace2; delta; pathology; delta variant ... See more keywords
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Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1055811

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed… read more here.

Keywords: k18 hace2; hace2; infection; hace2 mice ... See more keywords
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Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damages

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.950666

Abstract: The on-going COVID-19 pandemic has given rise to SARS-CoV-2 clades and variants with differing levels of symptoms and severity. To this end, we aim to systematically elucidate the changes in the pathogenesis as SARS-CoV-2 evolved… read more here.

Keywords: profiles across; k18 hace2; early pathogenesis; pathogenesis profiles ... See more keywords

DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 mice

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1166546

Abstract: The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead… read more here.

Keywords: cell; k18 hace2; silico predicted; cell epitopes ... See more keywords
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Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.840757

Abstract: The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 models or the potential infection of other animal species… read more here.

Keywords: cov variants; k18 hace2; omicron; delta omicron ... See more keywords