Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-021-01120-3
Abstract: Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1… read more here.
Keywords: molecular subgroups; diffuse midline; k27m; midline glioma ... See more keywords
Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1780-0
Abstract: mutant protein, and discuss the implications with regard to classification and grading. The first patient is a 30-year-old woman who presented with headaches and symptoms of increased intracranial pressure. Imaging demonstrated a heterogeneously enhancing mass… read more here.
Keywords: k27m mutant; expression; k27m; mutant protein ... See more keywords
H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-01975-4
Abstract: Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the… read more here.
Keywords: diffuse intrinsic; intrinsic pontine; differentiation; k27m ... See more keywords
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-020-04589-y
Abstract: The role of surgery in the management of pediatric non-pilocytic infiltrative thalamic gliomas needs to be revisited specifically with regard to molecularly defined subtypes. A retrospective review of a consecutive series of children operated on… read more here.
Keywords: k27m; k27m mutant; gliomas; role surgery ... See more keywords
Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma—A Diagnostic Dilemma for the Pathologist
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosciences in Rural Practice"
DOI: 10.1055/s-0041-1728231
Abstract: Diffuse midline glioma, H3 K27M-mutant, is a World Health Organization (WHO) grade IV glioma arising in pons, thalamus, and spinal cord. They show mutations resulting in replacement of lysine at position 27 by methionine (K27M)… read more here.
Keywords: glioma; diffuse midline; k27m mutant; k27m ... See more keywords
H3 K27M Mutation in Gangliogliomas can be Associated with Poor Prognosis
Sign Up to like & getrecommendations! Published in 2017 at "Brain Pathology"
DOI: 10.1111/bpa.12455
Abstract: Spinal cord (7, 15, 16) and brainstem (1, 2, 12, 14) diffuse midline gliomas have been shown to have H3F3A (K27M) mutations, which are paralleled by presence of strong, diffuse nuclear immunoreactivity using a high… read more here.
Keywords: tumor; ihc; k27m; mutation ... See more keywords
Co‐occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma
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DOI: 10.1111/bpa.12473
Abstract: Ganglioglioma (GG) is a grade I tumor characterized by alterations in the MAPK pathway, including BRAF V600E mutation. Recently, diffuse midline glioma with an H3 K27M mutation was added to the WHO 2016 classification as… read more here.
Keywords: braf v600e; grade; v600e; k27m ... See more keywords
Integrated clinical experience with ONC201 in H3 K27M glioma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.2059
Abstract: 2059Background: ONC201 is a DRD2 antagonist in Phase II trials for cancers that exhibit dysregulation of the dopamine pathway. We previously reported an objective response in the first recurrent H3 K27M midline glioma patient who… read more here.
Keywords: glioma; onc201 k27m; k27m glioma; clinical experience ... See more keywords
Clinical efficacy of ONC201 in thalamic H3 K27M-mutant glioma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.3617
Abstract: 3617Background: Diffuse midline gliomas, H3 K27M-mutant are associated with a poor prognosis compared to H3 wild-type gliomas and have no effective therapy following first-line radiation. ONC201 is... read more here.
Keywords: onc201 thalamic; clinical efficacy; efficacy onc201; k27m mutant ... See more keywords
Spinal Cord Diffuse Midline Glioma With Histone H3 K27M Mutation in a Pediatric Patient
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DOI: 10.3389/fsurg.2021.616334
Abstract: Background: Diffuse midline glioma (DMG) with histone H3 K27M mutation is a recently identified entity documented in the 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System. Spinal cord DMGs with… read more here.
Keywords: k27m; histone k27m; k27m mutation; spinal cord ... See more keywords