H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
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DOI: 10.1016/j.molcel.2020.09.028
Abstract: Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of… read more here.
Keywords: ezhip impede; k27m ezhip; prc2; impede h3k27 ... See more keywords