Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-021-01120-3
Abstract: Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1… read more here.
Keywords: molecular subgroups; diffuse midline; k27m; midline glioma ... See more keywords
Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1780-0
Abstract: mutant protein, and discuss the implications with regard to classification and grading. The first patient is a 30-year-old woman who presented with headaches and symptoms of increased intracranial pressure. Imaging demonstrated a heterogeneously enhancing mass… read more here.
Keywords: k27m mutant; expression; k27m; mutant protein ... See more keywords
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-020-04589-y
Abstract: The role of surgery in the management of pediatric non-pilocytic infiltrative thalamic gliomas needs to be revisited specifically with regard to molecularly defined subtypes. A retrospective review of a consecutive series of children operated on… read more here.
Keywords: k27m; k27m mutant; gliomas; role surgery ... See more keywords
Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma—A Diagnostic Dilemma for the Pathologist
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosciences in Rural Practice"
DOI: 10.1055/s-0041-1728231
Abstract: Diffuse midline glioma, H3 K27M-mutant, is a World Health Organization (WHO) grade IV glioma arising in pons, thalamus, and spinal cord. They show mutations resulting in replacement of lysine at position 27 by methionine (K27M)… read more here.
Keywords: glioma; diffuse midline; k27m mutant; k27m ... See more keywords
Abstract CT060: ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse glioma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct060
Abstract: Background: H3 K27M-mutant diffuse midline glioma is a universally fatal malignancy primarily affecting children and young adults. While radiotherapy (RT) provides transient benefit, no effective systemic therapy is currently available and current standard of care… read more here.
Keywords: mutant diffuse; k27m mutant; glioma; dordaviprone ... See more keywords
Malignant Progression of an MDS-Derived Cell Line Serves As an in Vitro Model for the Leukemic Evolution of MDS
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110583
Abstract: Myelodysplastic syndromes (MDS) have a risk of progression to acute myeloid leukemia (AML), but the deterioration mechanisms of MDS and the alteration points still remain to be elucidated. We previously established a myelodysplastic cell line,… read more here.
Keywords: mutant clones; k27m mutant; mds; cell ... See more keywords
Clinical efficacy of ONC201 in thalamic H3 K27M-mutant glioma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.3617
Abstract: 3617Background: Diffuse midline gliomas, H3 K27M-mutant are associated with a poor prognosis compared to H3 wild-type gliomas and have no effective therapy following first-line radiation. ONC201 is... read more here.
Keywords: onc201 thalamic; clinical efficacy; efficacy onc201; k27m mutant ... See more keywords
Pediatric Diffuse Midline Gliomas H3 K27M-Mutant and Non-Histone Mutant Midline High-Grade Gliomas in Neurofibromatosis Type 1 in Comparison With Non-Syndromic Children: A Single-Center Pilot Study
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00795
Abstract: Background: Pediatric neurofibromatosis type 1 (NF1) patients rarely develop aggressive central nervous system tumors. Among high-grade gliomas (HGGs), histone mutant diffuse midline gliomas (DMGs H3 K27M-mutant) have exceptionally been reported. The aim of this retrospectives… read more here.
Keywords: k27m mutant; midline; gliomas; histone ... See more keywords