Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1780-0
Abstract: mutant protein, and discuss the implications with regard to classification and grading. The first patient is a 30-year-old woman who presented with headaches and symptoms of increased intracranial pressure. Imaging demonstrated a heterogeneously enhancing mass… read more here.
Keywords: k27m mutant; expression; k27m; mutant protein ... See more keywords
Machine Learning-Based Multi-parametric MRI Radiomics for prediction of H3 K27M Mutation in Midline Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "World neurosurgery"
DOI: 10.1016/j.wneu.2021.03.135
Abstract: PURPOSE H3 K27M mutation in gliomas has prognostic implications. Previous MRI studies have reported variable rates of tumoral enhancement, necrotic changes and peritumoral edema in H3 K27M-mutant gliomas, with no distinguishing imaging features compared to… read more here.
Keywords: mri; midline gliomas; mutation; k27m mutation ... See more keywords
An H3F3A K27M-mutation in a sonic hedgehog medulloblastoma.
Sign Up to like & getrecommendations! Published in 2021 at "Brain pathology"
DOI: 10.1111/bpa.13024
Abstract: Medulloblastomas are malignant embryonal brain tumours that may harbour mutations in histone-modifying genes, while mutations in histone genes have not been detected to date. We here describe the first SHH medulloblastoma with H3 K27M mutation. This… read more here.
Keywords: h3f3a k27m; medulloblastoma; mutation sonic; mutation ... See more keywords
Abstract B44: Identification of epigenomic changes induced by H3 K27M mutation in glioblastoma using patient-derived and CRISPR/Cas9 edited cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca17-b44
Abstract: Background: Glioblastoma is a grade IV malignant brain tumor with poor prognosis and rapid disease progression. Recurrent somatic mutations in histone H3 genes have been identified in the majority of pediatric glioblastoma cases. The K27M… read more here.
Keywords: cell lines; chip; cell; k27m mutation ... See more keywords
Spinal Cord Diffuse Midline Glioma With Histone H3 K27M Mutation in a Pediatric Patient
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2021.616334
Abstract: Background: Diffuse midline glioma (DMG) with histone H3 K27M mutation is a recently identified entity documented in the 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System. Spinal cord DMGs with… read more here.
Keywords: k27m; histone k27m; k27m mutation; spinal cord ... See more keywords