K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response
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DOI: 10.1002/advs.202509817
Abstract: The ubiquitin chains perform diverse biological functions through different linkages. However, the understanding of non‐canonical K29‐linked ubiquitin chains is relatively limited. Exploring the physiological functions of K29‐linked ubiquitin chains beyond degradation is crucial for deciphering… read more here.
Keywords: k29 linked; cell proliferation; k29; linked ubiquitination ... See more keywords
Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination
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DOI: 10.1038/s41467-025-59569-6
Abstract: The K29/K48-linked ubiquitination generated by the cooperative catalysis of E3 ligase Ufd4 and Ubr1 is an enhanced protein degradation signal, in which Ufd4 is responsible for introducing K29-linked ubiquitination to K48-linked ubiquitin chains to augment… read more here.
Keywords: hect; ligase ufd4; k48; k29 k48 ... See more keywords