Pharmacologically reversible, loss of function mutations in the TM2 and TM4 inner pore helices of TREK-1 K2P channels
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48855-1
Abstract: A better understanding of the gating of TREK two pore domain potassium (K2P) channels and their activation by compounds such as the negatively charged activator, flufenamic acid (FFA) is critical in the search for more… read more here.
Keywords: function mutations; reversible loss; k2p channels; pharmacologically reversible ... See more keywords
Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46085
Abstract: Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels… read more here.
Keywords: potassium; k2p; k2p channels; two pore ... See more keywords
A gating mechanism of K2P channels by their selectivity filter
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac018
Abstract: Cellular excitability is determined by the flowof different ions across the cellmembrane, which is in turn controlled by the opening and closing of ion-permeable pores, the ion channels (Hille, 2001). For instance, in neurons, the… read more here.
Keywords: k2p; mechanism k2p; gating mechanism; membrane potential ... See more keywords
Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x19666210407152528
Abstract: Two-pore domain potassium (K2P) channels are a diverse family of potassium channels. K2P channels generate background leak potassium currents to regulate cellular excitability and are thereby involved in a wide range of neurological disorders. K2P… read more here.
Keywords: potassium; domain potassium; k2p channels; potassium channels ... See more keywords
The Insensitivity of TASK-3 K2P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19082437
Abstract: Two-pore domain K+ channels (K2P) display a characteristic extracellular cap structure formed by two M1-P1 linkers, the functional role of which is poorly understood. It has been proposed that the presence of the cap explains… read more here.
Keywords: cap; task; k2p channels; tea ... See more keywords