Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/s41590-017-0003-0
Abstract: Prolonged activation of interferon–STAT1 signaling is closely related to inflammatory autoimmune disorders, and therefore the identification of negative regulators of these pathways is important. Through high-content screening of 115 mouse RING-domain E3 ligases, we identified… read more here.
Keywords: rnf2; dna; stat1; interferon ... See more keywords
Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1407889
Abstract: ABSTRACT Ubiquitin chains are formed with 8 structurally and functionally distinct polymers. However, the functions of each polyubiquitin remain poorly understood. We developed a polyubiquitin-mediated fluorescence complementation (PolyUb-FC) assay using Kusabira Green (KG) as a… read more here.
Keywords: sqstm1 p62; polyub; linked polyubiquitin; k33 linked ... See more keywords