Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.150
Abstract: Pex4p is a peroxisomal E2 involved in ubiquitinating the conserved cysteine residue of the cycling receptor protein Pex5p. Previously, we demonstrated that Pex4p from the yeast Saccharomyces cerevisiae binds directly to the peroxisomal membrane protein… read more here.
Keywords: pex22p binding; k48 linked; pex4p; pex22p ... See more keywords
Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.067
Abstract: Ubiquitin-conjugating enzymes (E2) form thioester bonds with ubiquitin (Ub), which are subsequently transferred to target proteins for cellular progress. Ube2K/E2-25K (a class II E2 enzyme) contains a C-terminal ubiquitin-associated (UBA) domain that has been suggested… read more here.
Keywords: crystal structure; k48; ube2k 25k; k48 linked ... See more keywords
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00834-7
Abstract: Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological… read more here.
Keywords: regulates triggered; negatively regulates; k48 linked; march3 ... See more keywords
Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemical Biology"
DOI: 10.1038/s41589-021-00952-x
Abstract: Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis remains elusive due to the transient nature of Ub handover. Here, we… read more here.
Keywords: chain; k48 linked; linked chain; structure ... See more keywords
The retracted conformation of ubiquitin Ser65 phosphorylation inhibits the formation of K48-linked ubiquitin chains.
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience reports"
DOI: 10.1042/bsr20220968
Abstract: PINK1, as the first reported ubiquitin kinase, can phosphorylate ubiquitin (Ub) at Ser65 site, which regulates the structure and function of Ub monomer. However, the levels of PINK1 and phosphorylated Ub (pUb) are very low… read more here.
Keywords: k48 linked; ubiquitin ser65; linked ubiquitin; formation k48 ... See more keywords
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14853
Abstract: BACKGROUND AND PURPOSE Nox4 is the major NADPH isoform in the kidney and contributes to the pathogenesis of diabetic nephropathy (DN). However, the molecular mechanisms of increased Nox4 expression induced by hyperglycaemia remain to be… read more here.
Keywords: fibrosis; k48 linked; cx32; expression ... See more keywords
RNF123 Mediates Ubiquitination and Degradation of SOCS1 To Regulate Type I Interferon Production during Duck Tembusu Virus Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00095-23
Abstract: In recent years, posttranslational modification (PTM) has gradually become a research hot spot in the field of innate immunity regulation, and ubiquitination is one of the critical PTMs. DTMUV has seriously endangered the development of… read more here.
Keywords: degradation socs1; k48 linked; infection; linked ubiquitination ... See more keywords
Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000488475
Abstract: Background/Aims: The transcription factor Nrf2 is a master regulator of the antioxidant defense system, protecting cells from oxidative damage. We previously reported that the SUMO-targeted E3 ubiquitin ligase (STUbL), RING finger protein 4 (RNF4) accelerated… read more here.
Keywords: stabilization; stabilization nrf2; k48 linked; ring finger ... See more keywords