A Simple Electrochemical Aptamer Cytosensor for Direct Detection of Chronic Myelogenous Leukemia K562 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Electroanalysis"
DOI: 10.1002/elan.201600505
Abstract: A simple and rapid electrochemical aptamer cytosensor has been developed for direct detection of chronic myelogenous leukemia (CML) K562 cells based on a specific aptamer and a biotin conjugated concanavalin A (bio-ConA) detection probe. The… read more here.
Keywords: detection; k562 cells; k562; cytosensor ... See more keywords
Scavenger receptor class BI (SR-BI) mediates uptake of CPX-351 into K562 leukemia cells
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1513026
Abstract: Abstract Purpose: CPX-351 is a liposomal formulation of cytarabine and daunorubicin encapsulated at a 5:1 molar ratio, for the treatment of acute myeloid leukemia. The Scavenger Receptor class B type I (SR-BI) plays an important… read more here.
Keywords: k562; receptor class; uptake cpx; cpx 351 ... See more keywords
Evaluation of some genes and proteins involved in apoptosis on human chronic myeloid leukemia cells (K562 cells) by datura innoxia leaves aqueous extract
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1691661
Abstract: Abstract Datura innoxia (D. innoxia) has an extensive usage in traditional medicine and can also be used for intervention therapy in order to treat cancer. Despite of accomplishing some researches on D. innoxia mechanism, still… read more here.
Keywords: k562 cells; k562; aqueous extract; leaves aqueous ... See more keywords
4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line
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DOI: 10.1080/13880209.2017.1311351
Abstract: Abstract Context: 4-Nerolidylcatechol (4-NRC) has showed antitumor potential through apoptosis. However, its apoptotic mechanisms are still unclear, especially in leukemic cells. Objectives: To evaluate the cytotoxic potential of 4-NRC and its cell death pathways in… read more here.
Keywords: k562; cell; reduction cyclin; apoptosis ... See more keywords
6,7-Dimethoxycoumarin Influences the Erythroid Differentiation of Human Chronic Myelogenous Leukemia K562 Cells through Regulating FOXO3/p27 Signal Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/1138851
Abstract: Objective To study the pharmacological activity and the mechanism of action of natural compounds derived from 6,7-dimethoxycoumarin on the differentiation of human chronic myeloid leukemia K562 cells. Methods We use MTT assay (Sigma-Aldrich, USA) to… read more here.
Keywords: k562 cells; cell; leukemia; k562 ... See more keywords
CuO-TiO2-Chitosan-Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL-2 in the Human K562 Cancer Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "Bioinorganic Chemistry and Applications"
DOI: 10.1155/2022/9602725
Abstract: In this study, cells from human Chronic Myelogenous Leukemia (K562) were cultivated with CuO-TiO2-Chitosan-Berbamine nanocomposites. We examined nanocomposites using XRD, DLS, FESEM, TEM, PL, EDAX, and FTIR spectroscopy, as well as MTT for cytotoxicity, and… read more here.
Keywords: cuo tio2; tio2 chitosan; k562; berbamine nanocomposites ... See more keywords
Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells
Sign Up to like & getrecommendations! Published in 2018 at "AMB Express"
DOI: 10.1186/s13568-018-0606-3
Abstract: The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potential of B. subtilis lipopeptides (a… read more here.
Keywords: apoptosis; inhibition autophagy; k562; paraptosis ... See more keywords
Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126839
Abstract: TRIM28 is a scaffold protein that interacts with DNA-binding proteins and recruits corepressor complexes to cause gene silencing. TRIM28 contributes to physiological functions such as cell growth and differentiation. In the chronic myeloid leukemia cell… read more here.
Keywords: cell; cell proliferation; k562; trim28 ... See more keywords
New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030750
Abstract: Tyrosine kinase enzymes are among the primary molecular targets for the treatment of some human neoplasms, such as those in lung cancer and chronic myeloid leukemia. Mutations in the enzyme domain can cause resistance and… read more here.
Keywords: cancer; a549 k562; difluorinated compound; k562 ... See more keywords
The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase
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DOI: 10.3390/molecules27238270
Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease that activates multiple signaling pathways, causing cells to produce higher levels of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a major generator… read more here.
Keywords: skeletonema marinoi; cell; cell line; microalga skeletonema ... See more keywords
Exosomes released by imatinib‑resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib‑sensitive cells in the presence of imatinib.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oncology"
DOI: 10.3892/ijo.2020.5163
Abstract: Chronic myeloid leukemia (CML) is a malignant hematopoietic disorder distinguished by the presence of a BCR‑ABL1 fused oncogene with constitutive kinase activity. Targeted CML therapy by specific tyrosine kinase inhibitors (TKIs) leads to a marked… read more here.
Keywords: k562 cells; presence; k562; exosomes released ... See more keywords