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   Articles with "k562 adm" as a keyword



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Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug‐resistant K562/ADM cells to adriamycin

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2018.10.050

Abstract: Aims: Mounting studies have confirmed that cancer cells reprogram their metabolism during early carcinogenesis to develop many other hallmarks, and demonstrated a relationship between aerobic glycolysis and the occurrence of drug resistance. However, the molecular… read more here.

Keywords: glycolysis; aerobic glycolysis; k562 adm; drug ... See more keywords
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MicroRNA-145 promotes the apoptosis of leukemic stem cells and enhances drug-resistant K562/ADM cell sensitivity to adriamycin via the regulation of ABCE1

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recommendations! Published in 2020 at "International Journal of Molecular Medicine"

DOI: 10.3892/ijmm.2020.4675

Abstract: Leukemia is a type of cancer which originates in blood-forming tissues. MicroRNAs (miRNAs or miRs) have been shown to be involved leukemogenesis. In the present study, following the gain- and loss-function of miR-145 and ATP-binding… read more here.

Keywords: k562 adm; adm cells; cell; mir 145 ... See more keywords
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Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway.

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recommendations! Published in 2017 at "Molecular medicine reports"

DOI: 10.3892/mmr.2017.6189

Abstract: In human leukaemia, resistance to chemotherapy leads to treatment ineffectiveness or failure. Previous studies have indicated that cancers with increased levels of aerobic glycolysis are insensitive to numerous forms of chemotherapy and respond poorly to… read more here.

Keywords: leukaemia cells; glycolysis; k562 adm; mtor ... See more keywords
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AML-derived mesenchymal stem cells upregulate CTGF expression through the BMP pathway and induce K562-ADM fusiform transformation and chemoresistance

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recommendations! Published in 2019 at "Oncology Reports"

DOI: 10.3892/or.2019.7237

Abstract: Bone marrow-derived mesenchymal stem cells (MSCs), are the basic cellular components that make up the bone marrow microenvironment (BMM). In acute myeloid leukemia (AML), the morphology and function of MSCs changes in accordance with the… read more here.

Keywords: k562 adm; k562; bmp pathway; transformation ... See more keywords