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   Articles with "k562 cells" as a keyword



A Simple Electrochemical Aptamer Cytosensor for Direct Detection of Chronic Myelogenous Leukemia K562 Cells

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recommendations! Published in 2017 at "Electroanalysis"

DOI: 10.1002/elan.201600505

Abstract: A simple and rapid electrochemical aptamer cytosensor has been developed for direct detection of chronic myelogenous leukemia (CML) K562 cells based on a specific aptamer and a biotin conjugated concanavalin A (bio-ConA) detection probe. The… read more here.

Keywords: detection; k562 cells; k562; cytosensor ... See more keywords

AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity

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recommendations! Published in 2020 at "Current Medical Science"

DOI: 10.1007/s11596-020-2266-1

Abstract: Although the advent of tyrosine kinase inhibitors (TKIs) has dramatically improved the survival of patients with chronic myeloid leukaemia (CML), acquired drug resistance and TKI-insensitive leukaemic stem cells (LSCs) remain major obstacles to a CML… read more here.

Keywords: k562 cells; aicar; aicar decitabine; sensitivity k562 ... See more keywords

Method development for the analysis of PBMC-mediated killing of K562 cells by bovine colostrum.

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recommendations! Published in 2021 at "Journal of immunological methods"

DOI: 10.1016/j.jim.2021.113175

Abstract: BACKGROUND Colostrum is the first milk that supplies newborns with immune supporting peptides. Due to its heterogeneous and variable characteristics, standardized assays for assessment of its biological activities are a challenge. The current set of… read more here.

Keywords: bovine colostrum; mediated killing; k562 cells; killing k562 ... See more keywords

Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-64353-7

Abstract: Inference of directed biological networks is an important but notoriously challenging problem. The recent proliferation of large-scale CRISPR perturbation data provides a new opportunity to tackle this problem by leveraging the transcriptional response to the… read more here.

Keywords: k562 cells; structure; network; large scale ... See more keywords

The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep38105

Abstract: The simultaneous increases in blood lactic acid and erythrocytes after intense exercise could suggest a link between lactate and the erythropoiesis. However, the effects of lactic acid on erythropoiesis remain to be elucidated. Here, we… read more here.

Keywords: reactive oxygen; k562 cells; oxygen species; acid ... See more keywords

Evaluation of some genes and proteins involved in apoptosis on human chronic myeloid leukemia cells (K562 cells) by datura innoxia leaves aqueous extract

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recommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2019.1691661

Abstract: Abstract Datura innoxia (D. innoxia) has an extensive usage in traditional medicine and can also be used for intervention therapy in order to treat cancer. Despite of accomplishing some researches on D. innoxia mechanism, still… read more here.

Keywords: k562 cells; k562; aqueous extract; leaves aqueous ... See more keywords

Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca2+-dependent gap junction intercellular communication

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recommendations! Published in 2023 at "Chinese Medical Journal"

DOI: 10.1097/cm9.0000000000002554

Abstract: Abstract Background: Imatinib mesylate (IM) resistance is an emerging problem for chronic myeloid leukemia (CML). Previous studies found that connexin 43 (Cx43) deficiency in the hematopoietic microenvironment (HM) protects minimal residual disease (MRD), but the… read more here.

Keywords: k562 cells; cx43; resistance; bone marrow ... See more keywords

Cross‐talk of cholinergic and β‐adrenergic receptor signalling in chronic myeloid leukemia K562 cells

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recommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"

DOI: 10.1111/1440-1681.13627

Abstract: In many studies on breast, skin and intestinal cancers, β‐adrenergic receptor antagonists have been shown to inhibit cell proliferation and angiogenesis and increase apoptosis in cancers. Carbachol inhibits chronic myeloid leukaemia K562 cell proliferation. Beta‐blockers… read more here.

Keywords: myeloid; k562 cells; cell proliferation; chronic myeloid ... See more keywords

CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML

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recommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.18308

Abstract: Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in… read more here.

Keywords: k562 cells; crkl; mir 429; erythroid differentiation ... See more keywords

6,7-Dimethoxycoumarin Influences the Erythroid Differentiation of Human Chronic Myelogenous Leukemia K562 Cells through Regulating FOXO3/p27 Signal Pathway

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recommendations! Published in 2022 at "Journal of Oncology"

DOI: 10.1155/2022/1138851

Abstract: Objective To study the pharmacological activity and the mechanism of action of natural compounds derived from 6,7-dimethoxycoumarin on the differentiation of human chronic myeloid leukemia K562 cells. Methods We use MTT assay (Sigma-Aldrich, USA) to… read more here.

Keywords: k562 cells; cell; leukemia; k562 ... See more keywords

Abstract A021: Bone marrow mesenchymal stem cells tune autophagic circuitry of chronic myeloid leukemia cells in response to imatinib treatment

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recommendations! Published in 2018 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-17-a021

Abstract: Chronic myeloid leukemia (CML) is a stem cell disorder with the characteristic presence of chromosomal translocation resulting in the formation of Bcr-Abl protein tyrosine kinase. Within bone marrow, leukemia stem cells (LSCs) share a niche… read more here.

Keywords: cml; k562 cells; stem; leukemia ... See more keywords