Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease
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DOI: 10.1172/jci.insight.151496
Abstract: Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related pathologies is not clear. Particularly,… read more here.
Keywords: dominant negative; k619n; dat; dopamine transporter ... See more keywords