Organ defects of the Usp7K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical journal"
DOI: 10.1016/j.bj.2022.02.002
Abstract: BACKGROUND K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquitinated USP7 serves as a scaffold to anchor HIF1α,… read more here.
Keywords: organ defects; polyubiquitinated usp7; k63 polyubiquitinated; role ... See more keywords
The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-10-877563
Abstract: Hematopoietic stem cell (HSC) homeostasis is controlled by cytokine receptor-mediated Janus kinase 2 (JAK2) signaling. We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation. Whether a competing JAK2 deubiquitination activity exists is unknown.… read more here.
Keywords: cell; expansion; stem cell; hematopoietic stem ... See more keywords
RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia
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DOI: 10.1371/journal.ppat.1008618
Abstract: The genomic instability associated with adult T cell leukemia/lymphoma (ATL) is causally linked to Tax, the HTLV-1 viral oncoprotein, but the underlying mechanism is not fully understood. We have previously shown that Tax hijacks and… read more here.
Keywords: htlv; tax; genomic instability; k63 pubs ... See more keywords
The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin
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DOI: 10.26508/lsa.201800272
Abstract: Salmonella Typhi is estimated to cause 100,000–200,000 deaths annually, yet its infection strategy remains elusive. This article reports of the first Typhi-specific effector, which has an E3/E4 ubiquitin ligase activity and can uniquely bind K48-… read more here.
Keywords: ubiquitin ligase; k63; linked diubiquitin; stod ... See more keywords
Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1154203
Abstract: Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of… read more here.
Keywords: atxn3; k63; age dependent; spinocerebellar ataxia ... See more keywords