TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10887-x
Abstract: Frontotemporal dementia (FTD) is a neurodegenerative disease, resulting in progressive problems in language and/or behaviour and is often diagnosed before 65 years of age. Ubiquitin positive protein aggregates in the brain are among the key… read more here.
Keywords: mutation carriers; k63 ubiquitination; brain; tbk1 haploinsufficiency ... See more keywords
K63 ubiquitination in immune signaling
Sign Up to like & getrecommendations! Published in 2022 at "Trends in Immunology"
DOI: 10.1016/j.it.2021.12.005
Abstract: Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, is altered by… read more here.
Keywords: ubiquitination immune; ubiquitination; immune signaling; immunology ... See more keywords
AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13638
Abstract: Several aryl hydrocarbon receptor (AhR) agonists have been reported to promote the generation of regulatory T cells (Treg cells), and the action mechanisms need to be identified. In this study, we addressed the underlying mechanism… read more here.
Keywords: skp2; k63 ubiquitination; generation; lkb1 ... See more keywords