Abstract 4654: Hotspot mutations in the core spliceosomal protein SF3B1 promote breast tumorigenesis
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DOI: 10.1158/1538-7445.am2019-4654
Abstract: The core RNA splicing factor SF3B1 is targeted by recurrent hotspot mutations in leukemias and solid tumors with the K700E substitution observed in 2% of unselected breast cancer patients. These mutations promote usage of aberrant… read more here.
Keywords: hotspot mutations; cancer; k700e; breast cancer ... See more keywords