Probing intermolecular interactions and binding stability of kaempferol, quercetin and resveratrol derivatives with PPAR-γ: docking, molecular dynamics and MM/GBSA approach to reveal potent PPAR- γ agonist against cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1820380
Abstract: Abstract Peroxisome Proliferator-Activated Receptors-γ (PPAR-γ), a ligand-activated transcription factor, suggested having anti-inflammatory effects by activating the target genes when bound to the ligand. Herein, we examined a conformational analysis of 8708 derivatives of Kaempferol, Quercetin,… read more here.
Keywords: cancer; quercetin resveratrol; resveratrol; molecular dynamics ... See more keywords
Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24162888
Abstract: The inhibition of recombinant CpLIP2 lipase/acyltransferase from Candida parapsiolosis was considered a key model for novel antifungal drug discovery and a potential therapeutic target for candidiasis. Lipases have identified recently as potent virulence factors in… read more here.
Keywords: quercetin myricetin; kaempferol quercetin; inhibition; four flavonols ... See more keywords
Bioactivity and Therapeutic Potential of Kaempferol and Quercetin: New Insights for Plant and Human Health
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11192623
Abstract: Plant secondary metabolites, especially flavonoids, are major metabolites widely found in plants that play several key roles in plant defence and signalling in response to stress conditions. The most studied among these flavonoids are kaempferol… read more here.
Keywords: potential kaempferol; therapeutic potential; human health; plant ... See more keywords