Kainate receptors GluK1 and GluK2 differentially regulate synapse morphology
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22255
Abstract: The regulation of dendritic spine morphology is a critical aspect of neuronal network refinement during development and modulation of neurotransmission. Previous studies revealed that glutamatergic transmission plays a central role in synapse development. AMPA receptors… read more here.
Keywords: morphology; development; kainate receptors; gluk1 gluk2 ... See more keywords
Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites
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DOI: 10.1007/s11064-018-2654-0
Abstract: Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) mediating excitatory synaptic transmission. Cell surface expressed KARs modulate the excitability of neuronal networks. The transfer of iGluRs from the endoplasmic reticulum (ER) to… read more here.
Keywords: surface; ligand binding; binding sites; kainate receptors ... See more keywords
Domoic acid suppresses hyperexcitation in the network due to activation of kainate receptors of GABAergic neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.06.004
Abstract: Kainate receptors play an important role in the brain. They contribute to postsynaptic depolarization, modulate the release of neurotransmitters such as GABA and glutamate, affect the development of the neuronal network. At the same time,… read more here.
Keywords: network; domoic acid; kainate receptors; activation ... See more keywords
The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse
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DOI: 10.1038/s41598-018-24722-3
Abstract: Kainate receptors (KARs) are glutamate receptors with peak expression during late embryonic and early postnatal periods. Altered KAR-mediated neurotransmission and subunit expression are observed in several brain disorders, including epilepsy. Here, we examined the role… read more here.
Keywords: seizures neonatal; neurotransmission; kainate receptors; role ... See more keywords
Willardiine and Its Synthetic Analogues: Biological Aspects and Implications in Peptide Chemistry of This Nucleobase Amino Acid
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DOI: 10.3390/ph15101243
Abstract: Willardiine is a nonprotein amino acid containing uracil, and thus classified as nucleobase amino acid or nucleoamino acid, that together with isowillardiine forms the family of uracilylalanines isolated more than six decades ago in higher… read more here.
Keywords: chemistry; kainate receptors; nucleobase amino; amino acid ... See more keywords