Antimalarial Properties of Simplified Kalihinol Analogues
Sign Up to like & getrecommendations! Published in 2017 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.7b00013
Abstract: Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol… read more here.
Keywords: kalihinol; antimalarial properties; simplified kalihinol; kalihinol analogues ... See more keywords
Stereocontrolled Synthesis of Kalihinol C.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b01124
Abstract: We report a concise chemical synthesis of kalihinol C via a possible biosynthetic intermediate, "protokalihinol", which was targeted as a scaffold en route to antiplasmodial analogs. High stereocontrol of the kalihinol framework relies on a… read more here.
Keywords: kalihinol; stereocontrolled synthesis; synthesis kalihinol;