The role of the kallikrein‐kinin system, matrix metalloproteinases, and tissue inhibitors of metalloproteinases in the early restenosis of covered stents in the femoropopliteal arterial segment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2016.06.106
Abstract: Objective: The purpose of this study was to investigate the roles of the kallikrein‐kinin system and matrix metalloproteinases (MMPs) in the development of arterial restenosis attributable to intimal hyperplasia in the femoropopliteal arteries. Methods: This… read more here.
Keywords: kallikrein kinin; restenosis; kinin system; tissue ... See more keywords
What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?
Sign Up to like & getrecommendations! Published in 2020 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2020.109886
Abstract: Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease with fast spreading all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute respiratory syndrome by the injury caused in… read more here.
Keywords: kallikrein kinin; system; receptor; sars cov ... See more keywords
In vitro reconstitution of kallikrein-kinin system and progress curve analysis
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20221081
Abstract: Abstract Human kallikrein-kinin system (KKS) is a proteolytic cascade with two serine-protease zymogen couples (Factor XII and prekallikrein (PK) and their activated forms, FXIIa, PKa, respectively), releasing bradykinin by cleavage of native high-molecular-weight kininogen (nHK)… read more here.
Keywords: progress curve; curve analysis; curve; kallikrein kinin ... See more keywords
Inhibition of plasma kallikrein–kinin system to alleviate renal injury and arthritis symptoms in rats with adjuvant-induced arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2017.1418883
Abstract: Abstract Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Impairment of kidney functions in RA was observed. However, the mechanism of kidney injury of RA has not been clear. Plasma kallikrein–kinin system (KKS)… read more here.
Keywords: kallikrein kinin; arthritis; injury; plasma kallikrein ... See more keywords
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2022.2102578
Abstract: Abstract While coronavirus disease 2019 (COVID-19) begins as a respiratory infection, it progresses as a systemic disease involving multiorgan microthromboses that underly the pathology. SARS-CoV-2 enters host cells via attachment to the angiotensin-converting enzyme 2… read more here.
Keywords: kallikrein kinin; cov induced; pathology; sars cov ... See more keywords
The kallikrein–kinin system in diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000344
Abstract: Purpose of review Diabetic kidney disease (DKD) is one of the most common complications in diabetes mellitus and accounts for a large proportion of clinical nephrology practice. Studies have shown that the kallikrein–kinin system (KKS)… read more here.
Keywords: kallikrein kinin; kidney; nephrology; system ... See more keywords
The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4260-6
Abstract: BackgroundThe Kallikrein-Kinin System (KKS) has been found to play a role in tumor progression in several cancers. The KKS metabolic cascade depends on signalling through two cross talking receptors; bradykinin receptor 1 (B1R) and bradykinin… read more here.
Keywords: kallikrein kinin; cancer; receptor; progression ... See more keywords
Kallikrein–Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00156
Abstract: The Kallikrein–Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report,… read more here.
Keywords: kallikrein kinin; lupus; ifn; kinin system ... See more keywords
Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein–Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030541
Abstract: Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin–angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin–angiotensin system (RAS) and… read more here.
Keywords: kallikrein kinin; renin angiotensin; mice exposed; expression ... See more keywords
COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031714
Abstract: Mast cells (MCs) have relevant participation in inflammatory and vascular hyperpermeability events, responsible for the action of the kallikrein–kinin system (KKS), that affect patients inflicted by the severe form of COVID-19. Given a higher number… read more here.
Keywords: kallikrein kinin; lung; covid; mast cells ... See more keywords
Ameliorative Effect of Dabigatran on CFA-Induced Rheumatoid Arthritis via Modulating Kallikrein-Kinin System in Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810297
Abstract: Rheumatoid arthritis is an autoimmune disease that affects joints, leading to swelling, inflammation, and dysfunction in the joints. Recently, research efforts have been focused on finding novel curative approaches for rheumatoid arthritis, as current therapies… read more here.
Keywords: dabigatran; kallikrein kinin; cfa induced; rheumatoid arthritis ... See more keywords