Kallistatin suppresses cancer development by multi-factorial actions.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.03.011
Abstract: Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions.… read more here.
Keywords: kallistatin; cancer; factor; growth ... See more keywords
Increased kallistatin levels in patients with obesity and prediabetes compared to normal glucose tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine Research"
DOI: 10.1080/07435800.2017.1286671
Abstract: ABSTRACT Purpose: Kallistatin is a member of serine protease inhibitors (SERPIN) family, which has various functions such as regulation of cardiovascular function and blood vessels development. Its levels are elevated in patients with type 1… read more here.
Keywords: normal glucose; kallistatin; kallistatin levels; glucose tolerance ... See more keywords
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation
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DOI: 10.1155/2018/4138560
Abstract: Kallistatin was identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin exerts pleiotropic effects on angiogenesis, oxidative stress, inflammation, apoptosis, fibrosis, and tumor growth. Kallistatin levels are markedly reduced… read more here.
Keywords: kallistatin; stress inflammation; senescence; injury senescence ... See more keywords
Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling
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DOI: 10.2337/db21-0740
Abstract: It was reported previously that circulation levels of kallistatin, an endogenous Wnt signaling inhibitor, are increased in patients with diabetes. The current study was conducted to determine the role of kallistatin in delayed wound healing… read more here.
Keywords: wound healing; corneal wound; kallistatin; wnt ... See more keywords
Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation
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DOI: 10.3892/ijo.2017.3972
Abstract: Kallistatin has been recognized as an endogenous angiogenic inhibitor. However, its effects on lymphatic endothelial cells and lymphangiogenesis remain poorly understood. Lymphangiogenesis is involved in tumor metastasis via the lymphatic vasculature in various types of… read more here.
Keywords: proliferation migration; kallistatin; migration tube; lymphatic endothelial ... See more keywords