Rapid reduction of extremely high kappa free light chains in a patient with myeloma cast nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21619
Abstract: This report describes a patient with light chain myeloma and acute renal injury. Serum kappa free light chain (FLC) was extremely elevated, >33,000 mg/dL. Treatment with therapeutic plasma exchange (TPE) started day 2 for biopsy‐confirmed… read more here.
Keywords: cast nephropathy; kappa free; free light; tpe ... See more keywords
Kappa free light chains could predict early disease course in multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2019.02.001
Abstract: BACKGROUND Cerebrospinal fluid (CSF) kappa free light chains (KFLC) have been suggested as quantitative alternative to oligoclonal bands (OB) in multiple sclerosis (MS) diagnosis. Despite OB have been associated to poor disease prognosis, little is… read more here.
Keywords: sclerosis; free light; multiple sclerosis; light chains ... See more keywords
Performance of the Binding Site cerebrospinal fluid kappa free light chains assay
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical Biochemistry"
DOI: 10.1177/00045632251337616
Abstract: Background Measurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative to CSF oligoclonal bands due to its rapid turnaround time and… read more here.
Keywords: binding site; cerebrospinal fluid; csf; free light ... See more keywords
High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.827738
Abstract: Cerebrospinal kappa free light chain (KFLC)-index is a marker of intrathecal immunoglobulin synthesis that aids in the diagnosis of multiple sclerosis (MS). However, little evidence exists on its prognostic role. Our aim is to analyze… read more here.
Keywords: kflc index; index; kappa free; synthesis ... See more keywords
High levels of kappa free light chain synthesis predict cognitive decline in relapsing-remitting multiple sclerosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1106028
Abstract: Background Evolving evidence suggests that measurement of cerebrospinal fluid (CSF) kappa free light chain (KFLC) synthesis has high diagnostic sensitivity and specificity for multiple sclerosis (MS), but its prognostic ability is less investigated. The usefulness… read more here.
Keywords: kflc index; index; kappa free; synthesis ... See more keywords
Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12040475
Abstract: Background: Oligoclonal bands represent intrathecal immunoglobulin G (IgG) synthesis and play an important role in the diagnosis of multiple sclerosis (MS). Kappa free light chains (KFLC) are increasingly recognized as an additional biomarker for intrathecal… read more here.
Keywords: kappa free; light chains; non inflammatory; inflammatory neurological ... See more keywords
Kappa Free Light Chains in Multiple Sclerosis as a Marker of Intrathecal Humoral Response: A Sex-Disaggregated Study
Sign Up to like & getrecommendations! Published in 2024 at "Diagnostics"
DOI: 10.3390/diagnostics14242798
Abstract: Background: Kappa free light chains (KFLCs) are emerging as promising biomarkers for intrathecal B cell activity for diagnosing multiple sclerosis (MS) through cerebrospinal fluid (CSF) analysis. In this study, we evaluated the ability of KFLC… read more here.
Keywords: multiple sclerosis; study; sex; light chains ... See more keywords