Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.7b00484
Abstract: IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ,… read more here.
Keywords: canonical pathway; inhibitory kappa; kappa kinase; pathway ... See more keywords
Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc01245b
Abstract: Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a key regulator of the cannonical NF-κB pathway. IKKβ has been validated as a drug target for pathological conditions, which include chronic inflammatory diseases and… read more here.
Keywords: kinase; kappa kinase; factor kappa; inhibitor nuclear ... See more keywords