Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_427
Abstract: The kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on… read more here.
Keywords: kor; biosensors monitor; selective effects; receptor ... See more keywords
Antinociceptive Effects of Kappa-Opioid Receptor Agonists.
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DOI: 10.1007/164_2020_430
Abstract: Preclinical models that assess "pain" in rodents typically measure increases in behaviors produced by a "pain stimulus." A large literature exists showing that kappa opioid receptor (KOR) agonists can decrease these "pain-stimulated behaviors" following many… read more here.
Keywords: kor agonists; opioid receptor; pain; kappa opioid ... See more keywords
Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function.
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DOI: 10.1007/164_2021_433
Abstract: This chapter provides a general introduction to the dynorphins (DYNs)/kappa opioid receptor (KOR) system, including DYN peptides, neuroanatomy of the DYNs/KOR system, cellular signaling, and in vivo behavioral effects of KOR activation and inhibition. It… read more here.
Keywords: opioid receptor; system; fundamentals dynorphins; dynorphins kappa ... See more keywords
Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06118-4
Abstract: Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary opioid receptor of interest. However,… read more here.
Keywords: effects ketamine; kappa opioid; opioid receptors; swim test ... See more keywords
The long-term effects of stress and kappa opioid receptor activation on conditioned place aversion in male and female California mice
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.06.015
Abstract: &NA; Psychosocial stress leads to the activation of kappa opioid receptors (KORs), which induce dysphoria and facilitate depression‐like behaviors. However, less is known about the long‐term effects of stress and KORs in females. We examined… read more here.
Keywords: effects stress; long term; aversion; place aversion ... See more keywords
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.111
Abstract: Kappa-opioid receptor (KOR) is a member of G-protein coupled receptors (GPCRs) expressed in serotonergic neurons and neuronal terminals. The involvement of KOR ligands in nociception, diuresis, emotion, cognition, and immune system has been extensively studied.… read more here.
Keywords: opioid receptor; quantitative phosphoproteomics; phosphorylation; kappa opioid ... See more keywords
Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.07.012
Abstract: BACKGROUND Experiences of abuse and neglect during childhood are major predictors of the emergence of depressive and suicidal behaviors throughout life. The underlying biological mechanisms, however, remain poorly understood. Here, we focused on the opioid… read more here.
Keywords: receptor; child abuse; opioid receptor; kappa opioid ... See more keywords
Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity
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DOI: 10.1016/j.neuron.2016.12.005
Abstract: Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative affective states and stress reactivity. Excitatory inputs from the hippocampus and amygdala play a fundamental role in shaping the activity… read more here.
Keywords: opioid receptor; inhibition; modulation excitation; excitation inhibition ... See more keywords
Kappa opioid receptor modulation of endometriosis pain in mice
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DOI: 10.1016/j.neuropharm.2021.108677
Abstract: The kappa opioid receptor is a constituent of the endogenous opioid analgesia system widely expressed in somatosensory nervous pathways and also in endometrial tissues. This work investigates the possible involvement of kappa opioid receptor on… read more here.
Keywords: endometriosis; opioid receptor; mice; pain ... See more keywords
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics.
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2017.02.001
Abstract: Until the mid-60s, only the Mazatecs, an indigenous group from Oaxaca, Mexico, used Salvia Divinorum (S. divinorum) due to its hallucinogen properties. Later it was found that the hallucinogen effects of this plant were caused… read more here.
Keywords: agonist; salvinorin; opioid receptor; kappa opioid ... See more keywords
Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula
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DOI: 10.1016/j.ynstr.2020.100267
Abstract: The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine (DA)-mediated reward circuitry. Specifically, increased activity of the LHb is associated with drug… read more here.
Keywords: early life; stress; excitability; lateral habenula ... See more keywords