A novel predictive model of outcome in acute myeloid leukemia without favorable karyotype based on treatment strategy, karyotype and FLT3‐ITD mutational status
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25290
Abstract: REFERENCES 1. Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012; 120(12):2454-2465. 2. He R, Wiktor AE, Hanson CA, et al. Conventional karyotyping and fluorescence in… read more here.
Keywords: karyotype; myeloid leukemia; acute myeloid; strategy ... See more keywords
Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34780
Abstract: BACKGROUND Patients with acute myeloid leukemia (AML) who have tumor protein p53 (TP53) mutations or a complex karyotype have a poor prognosis, and hypomethylating agents are often used. The authors evaluated the efficacy of entospletinib,… read more here.
Keywords: myeloid leukemia; complex karyotype; substudy beat; karyotype ... See more keywords
Prognostic impact of complex karyotype on post‐transplant outcomes of myelofibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3058
Abstract: Chromosomal abnormalities in the role of prognostic factor for transplant patients with myelofibrosis (MF) are not fully investigated. Regarding complex karyotype (CK), we retrospectively analyzed 241 patients with primary and secondary MF who received a… read more here.
Keywords: transplant outcomes; complex karyotype; karyotype; group ... See more keywords
Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04550-8
Abstract: Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndrome (MDS) patients. However, more than 50% of low-risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged… read more here.
Keywords: undetectable karyotype; karyotype; normal karyotype; multiplex ligation ... See more keywords
Chromosomal study of Khawia abbottinae (Cestoda: Caryophyllidea): karyotype and localization of telomeric and ribosomal sequences after fluorescence in situ hybridization (FISH)
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06450-3
Abstract: An original cytogenetic study combining classical karyotype analysis and modern fluorescence in situ hybridization using telomeric (TTAGGG)n and ribosomal sequences (18S rDNA) was performed in Khawia abbottinae (Cestoda, Caryophyllidea), a parasite of Chinese false gudgeon… read more here.
Keywords: fluorescence situ; karyotype; study; ribosomal sequences ... See more keywords
Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2021.05.035
Abstract: BACKGROUND Chromosomal microarray analysis (CMA) improves the detection of genetic anomalies over standard karyotype and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of CMA in cases… read more here.
Keywords: chromosomal microarray; karyotype; study; cma ... See more keywords
Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience
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DOI: 10.1038/bmt.2016.293
Abstract: We analyzed the impact of cytogenetics on 193 children enrolled in two successive French trials (LAME89/91 and ELAM02), who received hematopoietic stem cell transplantation during CR1. Detailed karyotype was available for 66/74 (89%) in LAME89/91… read more here.
Keywords: karyotype; transplantation; cytogenetics outcome; lame89 elam02 ... See more keywords
Seeing the diagnosis on karyotype—SOX2 and eye development
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DOI: 10.1080/13816810.2017.1290119
Abstract: Karyotype has been a standard test for many decades in the context of multiple fetal or neonatal anomalies. This technique, however, has limited resolution, and deletions or duplications smaller than 5–7 Mb are not usually… read more here.
Keywords: array; diagnosis; karyotype; translocation ... See more keywords
Chromosome count and karyotype of two species of Clematis (Ranunculaceae)
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DOI: 10.1080/23818107.2017.1294503
Abstract: Abstract Karyotype morphometric data of two species of the genus Clematis L., a cosmopolitan and diverse genus, were studied. Clematis flammula is a diploid with 2n = 16 chromosomes. It exhibits a gradual decrease in… read more here.
Keywords: species clematis; karyotype; karyotype two; count karyotype ... See more keywords
Ribosomal DNA Instability as a Potential Cause of Karyotype Evolution
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DOI: 10.1093/molbev/msac221
Abstract: Karyotype refers to the configuration of the genome into a set of chromosomes. The karyotype difference between species is expected to impede various biological processes, such as chromosome segregation or meiotic chromosome pairing, potentially contributing… read more here.
Keywords: ribosomal dna; chromosome; karyotype; karyotype evolution ... See more keywords
External validation of karyotype nomogram to predict karyotype abnormalities in oligospermic men
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14446
Abstract: A male factor is responsible and contributory in 40% – 50% of infertility couples, and idiopathic male infertility accounts for over 50% of male infertility Karyotype analysis and Y-chromosome microdeletions for male infertility play an… read more here.
Keywords: external validation; karyotype; karyotype analysis; infertility ... See more keywords