An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-021-01287-2
Abstract: The aims of the study were to investigate the relationship between aldehyde dehydrogenase 1 family member A2 (ALDH1A2) and Kashin-Beck disease (KBD), explore the effects of the rs3204689 polymorphism and methylation status on the expression… read more here.
Keywords: aldh1a2 associated; chinese population; kashin beck; beck disease ... See more keywords
Relationship of the mobile forms of calcium and strontium in soils with their accumulation in meadow plants in the area of Kashin–Beck endemia
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Geochemistry and Health"
DOI: 10.1007/s10653-019-00323-5
Abstract: This study was aimed at assessment of strontium and calcium mobility in soils and their accumulation with plants in the areas endemic for Kashin–Beck disease in Eastern Transbaikalia. The strontium and calcium mobility levels were… read more here.
Keywords: soils accumulation; calcium; strontium; kashin beck ... See more keywords
Dysregulation of Transcription Profile of Selenoprotein in Patients with Kashin-Beck Disease and Its Effect on Se Deficiency-Induced Chondrocyte Apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02772-5
Abstract: Kashin-Beck disease (KBD) is a chronic, degenerative osteoarthropathy related to selenium (Se) deficiency. Se participates in the synthesis of selenoprotein in the form of selenocysteine. In total, 25 selenoproteins, encoded by 25 genes, are currently… read more here.
Keywords: chondrocyte apoptosis; apoptosis; mrna levels; beck disease ... See more keywords
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.023
Abstract: OBJECTIVE The aim of this study was to investigate FGF8 and FGFR3 expression in clinical samples of Kashin-Beck disease (KBD), an endemic osteochondropathy found in China, as well as in pre-clinical models of this disease.… read more here.
Keywords: hypertrophic chondrocytes; fgf8 fgfr3; deep zone; fgfr3 ... See more keywords
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109440
Abstract: There are a pretty number of research demonstrating that ADAMTS4 and ADAMTS5 playing primary roles in the degradation of cartilage during inflammatory joint diseases like osteoarthritis (OA). Because Kashin-Beck Disease (KBD) has been found to… read more here.
Keywords: adamts4 adamts5; adamts5 may; molecular therapeutic; therapeutic targets ... See more keywords
Patients with Kashin-Beck Disease Obtained Lower Functional Activities but Better Satisfaction Than Patients with Osteoarthritis After Total Knee Arthroplasty: A Retrospective Study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s388401
Abstract: Background Increasingly, patient satisfaction after total knee arthroplasty (TKA) is being recognized as an important measure of health-care quality in osteoarthritis (OA) patients. But satisfaction after TKA has not yet been reported in Kashin-Beck disease… read more here.
Keywords: knee arthroplasty; kbd; satisfaction; knee ... See more keywords
Growth surveillance indices and Kashin-Beck Disease in children
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicine and Life"
DOI: 10.25122/jml-2021-0125
Abstract: Selenium, manganese, and calcium are necessary elements for maintaining normal growth and skeleton formation. Kashin-Beck disease mostly occurs in children, resulting in deformities, dwarfism, and disabilities. Selenium deficiency was considered a risk factor in China,… read more here.
Keywords: beck disease; surveillance; growth; disease ... See more keywords
Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1053685
Abstract: The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck disease… read more here.
Keywords: ccnb1 ccng1; beck disease; disease; differential expression ... See more keywords
Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.942326
Abstract: Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy that exhibits some similar characteristics to osteoarthritis (OA) but with different etiologies and pathogeneses. In addition to cartilage damage, microstructural changes of bone were observed in KBD.… read more here.
Keywords: bone; kbd; analysis; histopathology ... See more keywords
Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph18010011
Abstract: Kashin-Beck Disease (KBD) is one of major endemic diseases in China. In this study, we estimated the health loss from KBD in Qamdo district of Tibet using the years lived with disability (YLD) metric and… read more here.
Keywords: health loss; yld; health; kashin beck ... See more keywords