Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09270-2
Abstract: The TFIIH subunit XPB is involved in combined Xeroderma Pigmentosum and Cockayne syndrome (XP-B/CS). Our analyses reveal that XPB interacts functionally with KAT2A, a histone acetyltransferase (HAT) that belongs to the hSAGA and hATAC complexes.… read more here.
Keywords: chromatin; kat2a; tfiih; gene expression ... See more keywords
Abstract 2907: Targeting the epigenetic regulator KAT2a in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2907
Abstract: Gene expression frequently requires the dynamic remodelling of the chromatin architecture to orchestrate the assembly of transcriptional protein complexes at the promoter sites of DNA. Chromatin remodelling complexes are multicomponent proteins that facilitate reorganisation of… read more here.
Keywords: targeting epigenetic; regulator kat2a; epigenetic regulator; gene expression ... See more keywords