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   Articles with "kat6a" as a keyword



A Novel Frameshift Mutation in KAT6A Is Associated with Pancraniosynostosis.

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recommendations! Published in 2021 at "Journal of pediatric genetics"

DOI: 10.1055/s-0040-1710330

Abstract: De novo heterozygous mutations in the KAT6A gene give rise to a distinct intellectual disability syndrome, with features including speech delay, cardiac anomalies, craniofacial dysmorphisms, and craniosynostosis. Here, we reported a 16-year-old girl with a… read more here.

Keywords: mutation kat6a; kat6a associated; pancraniosynostosis; frameshift mutation ... See more keywords

Abstract 1739: Identification of a potent and selective KAT6A/6B inhibitor: HW321005 exhibits strong antitumor activity in KAT6A-high ER+/HER2− breast cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-1739

Abstract: KAT6A and its paralog KAT6B are histone lysine acetyltransferases (HATs) that regulate gene transcription via the acetylation of histones. Dysregulation of KAT6 leads to lineage-specific gene expression changes in cancer. Overexpression of KAT6 is associated… read more here.

Keywords: cancer; breast cancer; kat6a; hw321005 ... See more keywords

Abstract 457: QLS1304, a highly potent and selective KAT6A/B inhibitor treating ER+HER2- breast cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-457

Abstract: KAT6A and KAT6B, members of the MYST family of lysine acetyltransferases, are implicated in estrogen receptor-positive (ER+) breast cancer. KAT6A amplification occurs in about 10% of these patients, linking to overexpression and poorer outcomes. KAT6B… read more here.

Keywords: cancer; breast cancer; her2 breast; kat6a ... See more keywords

The Expression of Histone Acetyltransferase KAT6A in Non-small Cell Lung Cancer

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recommendations! Published in 2022 at "AntiCancer Research"

DOI: 10.21873/anticanres.16080

Abstract: Background/Aim: KAT6A is considered a factor influencing carcinogenesis. Due to the fact that lung cancer is one of the leading causes of death, the aim of our study was to evaluate KAT6A expression in non-small… read more here.

Keywords: lung cancer; cell; expression; lung ... See more keywords