Insulin sensitivity in the aged heart is improved by down-regulation of KAT7 in vivo and in vitro
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DOI: 10.1080/15384101.2021.2018811
Abstract: ABSTRACT Insulin has an important regulatory effect on the heart, and the important regulatory effect of insulin on the heart is the regulation of substrate utilization. Studies have shown that aging is closely related to… read more here.
Keywords: insulin resistance; insulin sensitivity; heart; kat7 ... See more keywords
LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA
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DOI: 10.1093/nar/gkz747
Abstract: Abstract Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our… read more here.
Keywords: lyar; rrna synthesis; rdna; kat7 ... See more keywords