Ability of CP‐532,903 to protect mouse hearts from ischemia/reperfusion injury is dependent on expression of A3 adenosine receptors in cardiomyoyctes
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.01.022
Abstract: Graphical abstract Figure. No caption available. &NA; A3 adenosine receptor (A3AR) agonists are effective at limiting injury caused by ischemia/reperfusion injury of the heart in experimental animal models. However, understanding of their mechanism of action,… read more here.
Keywords: katp; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Cognitive deficits and impaired hippocampal long-term potentiation in KATP-induced DEND syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109721118
Abstract: Significance Gain-of-function (GOF) mutations in the ATP-sensitive potassium (KATP) channel cause neonatal diabetes, with some individuals exhibiting developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. In this study, we uncover the direct effects of neuronal… read more here.
Keywords: gof mutations; katp; katp gof; cognitive deficits ... See more keywords
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2090667
Abstract: ABSTRACT ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms regulating KATP channel internalization… read more here.
Keywords: cardiac katp; katp; katp channel; katp channels ... See more keywords
Glucose‐Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet &agr; Cells
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2017-00282
Abstract: &NA; The secretion of glucagon by islet &agr; cells is normally suppressed by high blood glucose, but this suppressibility is impaired in patients with diabetes or cystic fibrosis (CF), a disease caused by mutations in… read more here.
Keywords: glucagon secretion; secretion; agr cells; cftr ... See more keywords
Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db19-1256
Abstract: Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this “glucose effectiveness” is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous… read more here.
Keywords: glucose effectiveness; katp channels; katp; hyperglycemia ... See more keywords
KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1161117
Abstract: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion. Timely diagnosis and effective treatment… read more here.
Keywords: katp channel; katp; congenital hyperinsulinism; progress ... See more keywords
Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01122
Abstract: ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and… read more here.
Keywords: tolerance; channel activity; katp; katp channel ... See more keywords
Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.868401
Abstract: ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in… read more here.
Keywords: therapeutic strategies; katp; clinical therapeutic; katp channels ... See more keywords
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1033216
Abstract: There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have cardioprotective effects. n-3 PUFAs cause vasodilation in hypertensive patients, in part controlled by increased membrane… read more here.
Keywords: mouse aorta; katp; vasodilation; aorta mesenteric ... See more keywords
Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52373
Abstract: We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin… read more here.
Keywords: ankyrin mediates; targeting katp; mediates targeting; katp channels ... See more keywords