Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel.
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2722
Abstract: Inhibition of the mammalian target of rapamycin (mTOR) with the macrolide rapamycin or pharmacological suppression of KATP channel opening translated to scar expansion of the myocardial infarcted (MI) adult female rodent heart. The present study… read more here.
Keywords: mtor; katp channel; scar expansion;
The 40-Hz White Light-Emitting Diode (LED) Improves the Structure-Function of the Brain Mitochondrial KATP Channel and Respiratory Chain Activities in Amyloid Beta Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02681-7
Abstract: It has been described that using noninvasive exposure to 40-Hz white light LED reduces amyloid-beta, a peptide thought to initiate neurotoxic events in Alzheimer's disease (AD). However, the mechanisms remain to be identified. Since AD… read more here.
Keywords: katp channel; respiratory chain; channel; white light ... See more keywords
Hydrogen sulfide donor, NaHS, stimulates ANP secretion via the KATP channel and the NOS/sGC pathway in rat atria
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2018.04.005
Abstract: HIGHLIGHTSNaHS and Na2S augmented high stretch‐induced ANP secretion whereas GYY4137 and sodium thiosulfate did not.NaHS‐stimulated ANP secretion was blocked by the pretreatment with inhibitor for KATP channel, NOS, sGC, PI3K or protein kinase B.The attenuation… read more here.
Keywords: secretion; katp channel; anp secretion; rat atria ... See more keywords
Olanzapine-induced insulin resistance may occur via attenuation of central KATP channel-activation
Sign Up to like & getrecommendations! Published in 2021 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2020.12.005
Abstract: Antipsychotic use is associated with an increased risk of type 2 diabetes. Recent work suggests antipsychotics can induce insulin resistance immediately and independently of weight gain, and that this may occur via the central nervous… read more here.
Keywords: katp channel; channel; channel activation; olanzapine ... See more keywords
New insights into KATP channel gene mutations and neonatal diabetes mellitus
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-020-0351-y
Abstract: The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events that results in insulin release. Metabolically generated changes in the… read more here.
Keywords: katp channel; genes encoding; diabetes mellitus; mutations genes ... See more keywords
Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30175-5
Abstract: We recently reported the reduced ATP-sensitive potassium (KATP) channel activities in the transgenic mouse heart overexpressing the vascular type KATP channel pore-forming subunit (Kir6.1). Although dysfunction of cardiac KATP channel has been nominated as a… read more here.
Keywords: transgenic mice; heart; mouse heart; katp channel ... See more keywords
Involvement of the L-arginine/Nitric Oxide/Cyclic GMP/KATP Channel Pathway and PPARγ Receptors in the Peripheral Antinociceptive Effect of Carbamazepine.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/a-0959-5896
Abstract: Carbamazepine has been shown to exert analgesic effects in clinical and experimental pain situation. This study was conducted to evaluate its potential peripheral antinociceptive effects and the possible involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARγ… read more here.
Keywords: carbamazepine; katp channel; channel pathway; paw ... See more keywords
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2090667
Abstract: ABSTRACT ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms regulating KATP channel internalization… read more here.
Keywords: cardiac katp; katp; katp channel; katp channels ... See more keywords
Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db17-0880
Abstract: The mechanisms of control of glucagon secretion are largely debated. In particular, the paracrine role of somatostatin (SST) is unclear. We studied its role in the control of glucagon secretion by glucose and KATP channel… read more here.
Keywords: sst; katp channel; effect; glucagonostatic effect ... See more keywords
KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1161117
Abstract: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion. Timely diagnosis and effective treatment… read more here.
Keywords: katp channel; katp; congenital hyperinsulinism; progress ... See more keywords
Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01122
Abstract: ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and… read more here.
Keywords: tolerance; channel activity; katp; katp channel ... See more keywords