Therapeutic potential of ATP-sensitive potassium channels in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.01.003
Abstract: In the past decade, there was an increasing interest in the therapeutic potential targeting ATP-sensitive potassium (KATP) channels for an effective treatment of Parkinson's disease (PD). KATP channels are widely expressed in the central nervous… read more here.
Keywords: sensitive potassium; katp channels; atp sensitive; parkinson disease ... See more keywords
KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172828
Abstract: The venoarteriolar reflex is a local mechanism that induces vasoconstriction during venous congestion in various tissues, including skin. This response is thought to play a critical role in minimizing capillary damage or edema resulting from… read more here.
Keywords: reflex; katp channels; nos cox; skin ... See more keywords
Dexmedetomidine attenuates the induction and reverses the progress of 6-hydroxydopamine- induced parkinsonism; involvement of KATP channels, alpha 2 adrenoceptors and anti-inflammatory mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114743
Abstract: BACKGROUND Studies have shown that dexmedetomidine (DEX), a potent α2-adrenoceptors agonist provides neuroprotection through suppression of inflammatory response. In present study, we examined effect of DEX and its underlying mechanisms on the induction and progress… read more here.
Keywords: katp channels; induced parkinsonism; ohda induced; dex ... See more keywords
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2090667
Abstract: ABSTRACT ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms regulating KATP channel internalization… read more here.
Keywords: cardiac katp; katp; katp channel; katp channels ... See more keywords
Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.14803
Abstract: ATP‐sensitive K+ channels (KATP) have been implicated in the regulation of resting vascular smooth muscle membrane potential and tone. However, whether KATP channels modulate skeletal muscle microvascular hemodynamics at the capillary level (the primary site… read more here.
Keywords: skeletal muscle; muscle; katp channels; resting skeletal ... See more keywords
The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0221
Abstract: Objective Lipotoxicity-induced pancreatic β cell-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we investigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the relationship… read more here.
Keywords: endocytosis katp; insulin secretion; katp channels;
Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db19-1256
Abstract: Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this “glucose effectiveness” is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous… read more here.
Keywords: glucose effectiveness; katp channels; katp; hyperglycemia ... See more keywords
Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.868401
Abstract: ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in… read more here.
Keywords: therapeutic strategies; katp; clinical therapeutic; katp channels ... See more keywords
Early Effects of Metabolic Syndrome on ATP-Sensitive Potassium Channels from Rat Pancreatic Beta Cells
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12040365
Abstract: Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 two diabetes mellitus and cardiovascular diseases. MS leads to pancreatic beta cell exhaustion and decreased insulin secretion through… read more here.
Keywords: katp channels; beta; metabolic syndrome; pancreatic beta ... See more keywords
Expression of KATP channels in human cervical cancer: Potential tools for diagnosis and therapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8165
Abstract: Various ion channels, including ATP-sensitive potassium (KATP) channels, are expressed in cancer and have been suggested as potential tumor markers and therapeutic targets. KATP channels are composed of at least two types of subunit, an… read more here.
Keywords: katp channels; cervical cancer; expression; cancer ... See more keywords
Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52373
Abstract: We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin… read more here.
Keywords: ankyrin mediates; targeting katp; mediates targeting; katp channels ... See more keywords