Pharmacokinetic profile and oral bioavailability of Kaurenoic acid from Copaifera spp. in rats.
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DOI: 10.1016/j.fitote.2018.05.013
Abstract: Kaurenoic acid (KA) is a kaurane diterpene found in several medicinal plants that displays biological activities, such as anti-inflammatory, smooth muscle relaxant and hypotensive response. However, there are no pharmacokinetic data available about this molecule.… read more here.
Keywords: oral bioavailability; bioavailability; pharmacokinetic profile; profile oral ... See more keywords
Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons
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DOI: 10.3390/ph16030343
Abstract: Kaurenoic acid (KA) is a diterpene extracted from Sphagneticola trilobata (L.) Pruski. KA presents analgesic properties. However, the analgesic activity and mechanisms of action of KA in neuropathic pain have not been investigated so far;… read more here.
Keywords: nitric oxide; constriction injury; neuropathic pain; pain ... See more keywords