Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis
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DOI: 10.1007/s00264-018-4029-1
Abstract: PurposeKashin-Beck disease (KBD) is an endemic osteoarthropathy, and the severe knee pain and functional limitations were seriously affecting the quality of life in patients with end-stage KBD. We retrospectively evaluated the clinical outcomes and the… read more here.
Keywords: knee pain; knee; beck disease; quality life ... See more keywords
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease
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DOI: 10.1177/19476035221087706
Abstract: Objective To investigate the expression of Hedgehog (HH) signaling pathway proteins in knee articular cartilage from Kashin-Beck disease (KBD) and osteoarthritis (OA) patients. Methods Knee articular cartilage samples were collected from normal (N), OA, and… read more here.
Keywords: shh; ihh; pathway proteins; hedgehog ... See more keywords
Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease
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DOI: 10.1186/s12891-021-04952-9
Abstract: Background The etiology of Kashin-Beck disease (KBD), an endemic osteochondropathy, is largely unknown. Matrix metalloproteinase-3 (MMP-3) plays a central role in the initiation and progression of cartilage destruction, however, no study has reported on the… read more here.
Keywords: expression mmp; mmp timp; articular cartilage; cartilage ... See more keywords
Patients with Kashin-Beck Disease Obtained Lower Functional Activities but Better Satisfaction Than Patients with Osteoarthritis After Total Knee Arthroplasty: A Retrospective Study
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DOI: 10.2147/cia.s388401
Abstract: Background Increasingly, patient satisfaction after total knee arthroplasty (TKA) is being recognized as an important measure of health-care quality in osteoarthritis (OA) patients. But satisfaction after TKA has not yet been reported in Kashin-Beck disease… read more here.
Keywords: knee arthroplasty; kbd; satisfaction; knee ... See more keywords
Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis
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DOI: 10.3389/fgene.2022.942326
Abstract: Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy that exhibits some similar characteristics to osteoarthritis (OA) but with different etiologies and pathogeneses. In addition to cartilage damage, microstructural changes of bone were observed in KBD.… read more here.
Keywords: bone; kbd; analysis; histopathology ... See more keywords
Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China
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DOI: 10.3390/ijerph18010011
Abstract: Kashin-Beck Disease (KBD) is one of major endemic diseases in China. In this study, we estimated the health loss from KBD in Qamdo district of Tibet using the years lived with disability (YLD) metric and… read more here.
Keywords: health loss; yld; health; kashin beck ... See more keywords