Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2425494122
Abstract: Significance An approach to turn old drugs into new drugs is “selective optimization of a side activity (SOSA).” Here, we modified the 1,4-dihydropyridine nucleus and transformed its side activity (weak blockade of the calcium-activated potassium… read more here.
Keywords: calcium activated; activated potassium; potassium channel; kca ... See more keywords
Effects of KCa channels on biological behavior of trophoblasts
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DOI: 10.1515/biol-2022-0462
Abstract: Abstract The Ca2+-activated potassium (KCa) channels are involved in many cellular functions, but their roles in trophoblasts are unclear. This study aimed to clarify the effects of KCa channels on the biological behavior of trophoblasts.… read more here.
Keywords: effects kca; behavior trophoblasts; channels biological; kca ... See more keywords
The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators
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DOI: 10.3389/fphar.2019.00972
Abstract: Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain… read more here.
Keywords: cam; kca channel; channel activators; structure ... See more keywords
Challenges in the Therapeutic Targeting of KCa Channels: From Basic Physiology to Clinical Applications
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DOI: 10.3390/ijms25052965
Abstract: Calcium-activated potassium (KCa) channels are ubiquitously expressed throughout the body and are able to regulate membrane potential and intracellular calcium concentrations, thereby playing key roles in cellular physiology and signal transmission. Consequently, it is unsurprising… read more here.
Keywords: physiology; therapeutic targeting; kca channels; kca ... See more keywords