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   Articles with "kca channel" as a keyword



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Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.

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recommendations! Published in 2019 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2019.172462

Abstract: Transient receptor potential vanilloid 4 (TRPV4) channels exist in the endothelial cells of cutaneous blood vessels and the secretory cells of eccrine sweat glands. We assessed if exogenous TRPV4 channel activation elicits cutaneous vasodilatation and… read more here.

Keywords: trpv4 channel; vasodilatation; kca channel; sweat rate ... See more keywords
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Impairment of Coronary Endothelial Function by Hypoxia-Reoxygenation Involves TRPC3 Inhibition-mediated KCa Channel Dysfunction: Implication in Ischemia-Reperfusion Injury

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-06247-3

Abstract: Despite increasing knowledge of the significance of calcium-activated potassium (KCa) and canonical transient receptor potential (TRPC) channels in endothelial physiology, no studies so far have investigated the link between these two distinct types of channels… read more here.

Keywords: hypoxia reoxygenation; kca channel; dysfunction; inhibition ... See more keywords
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Are there superagonists for calcium-activated potassium channels?

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recommendations! Published in 2017 at "Channels"

DOI: 10.1080/19336950.2017.1376971

Abstract: Similar to GABAA receptor-channels the calciummediated gating of the small-conductance KCa2 and the intermediate-conductance KCa3.1 channels can be positively or negatively modulated by small molecule drugs, which, in analogy to the GABA field, have been… read more here.

Keywords: kca channel; calmodulin; ska 121; calcium ... See more keywords
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Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5726664

Abstract: Atherosclerosis is a major risk factor for cardiovascular disease and is induced by hyperlipidemia and endothelial dysfunction (ED), leading to fatty plaque formation and impaired vascular function. Pharmacological activation of endothelial Ca2+-activated K+ channels (KCa2.3… read more here.

Keywords: kca channel; function; physiology; atherosclerosis ... See more keywords
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The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

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recommendations! Published in 2019 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2019.00972

Abstract: Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain… read more here.

Keywords: cam; kca channel; channel activators; structure ... See more keywords