SKA‐31, an activator of endothelial Ca2+‐activated K+ channels evokes robust vasodilation in rat mesenteric arteries
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.006
Abstract: Abstract It is now well recognized that endothelial KCa2.3 and KCa3.1 channel activities contribute to dilation of resistance arteries via endothelium‐mediated hyperpolarization and vascular smooth muscle relaxation. In this study, we have investigated the functional… read more here.
Keywords: kca2 kca3; vasodilation; mesenteric arteries; channel ... See more keywords
Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)–Dependent Vasodilation and Blood Pressure Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318820
Abstract: Background: S1P (sphingosine-1-phosphate) has been reported to possess vasodilatory properties, but the underlying pathways are largely unknown. Methods: Isolated mouse mesenteric artery and endothelial cell models were used to determine S1P-induced vasodilation, intracellular calcium, membrane… read more here.
Keywords: kca3; vasodilation blood; kca2 kca3; s1p ... See more keywords