Co‐staining of KCa3.1 Channels in NSCLC Cells with a Small‐Molecule Fluorescent Probe and Antibody‐Based Indirect Immunofluorescence
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000652
Abstract: The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was… read more here.
Keywords: indirect immunofluorescence; antibody; kca3; channel ... See more keywords
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small‐Molecule Fluorescent Probes
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DOI: 10.1002/cmdc.202200551
Abstract: The Ca2+ activated K+ channel KCa3.1 is overexpressed in several human tumor cell lines, e. g. clear cell renal carcinoma, prostate cancer, non‐small cell lung cancer. Highly aggressive cancer cells use this ion channel for key… read more here.
Keywords: imaging kca3; tumor cells; kca3; kca3 channels ... See more keywords
The potassium channel KCa3.1 promotes cell proliferation by activating SKP2 and metastasis through the EMT pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32121
Abstract: The intermediate conductance calcium‐activated potassium channel (KCa3.1) plays an important role in maintaining intracellular calcium homeostasis and is involved in the tumorigenesis of many human cancers. However, it is unknown whether KCa3.1 plays a role… read more here.
Keywords: hepatocellular carcinoma; hcc; cell proliferation; potassium channel ... See more keywords
Why do platelets express K+ channels?
Sign Up to like & getrecommendations! Published in 2021 at "Platelets"
DOI: 10.1080/09537104.2021.1904135
Abstract: Abstract Potassium ions have widespread roles in cellular homeostasis and activation as a consequence of their large outward concentration gradient across the surface membrane and ability to rapidly move through K+-selective ion channels. In platelets,… read more here.
Keywords: channels platelets; platelets express; kca3; express channels ... See more keywords
Retromer involvement in trafficking of the calcium-activated K channel, KCa3.1
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733913
Abstract: The intermediate-conductance Ca2+-activated K+ channel KCa3.1 ( KCNN4) regulates many physiological processes, including, water and electrolyte transport in polarised epithelia and vascular tone. Crucial for KCa3.1 function is the regulation of the number of channels… read more here.
Keywords: retromer; snx27; activated channel; trafficking kca3 ... See more keywords
Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)–Dependent Vasodilation and Blood Pressure Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318820
Abstract: Background: S1P (sphingosine-1-phosphate) has been reported to possess vasodilatory properties, but the underlying pathways are largely unknown. Methods: Isolated mouse mesenteric artery and endothelial cell models were used to determine S1P-induced vasodilation, intracellular calcium, membrane… read more here.
Keywords: kca3; vasodilation blood; kca2 kca3; s1p ... See more keywords
The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1682-2
Abstract: BackgroundRecent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra.… read more here.
Keywords: microgliosis; parkinson disease; mouse model; kca3 ... See more keywords
Functional Roles of the Ca2+-activated K+ Channel, KCa3.1, in Brain Tumors
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DOI: 10.2174/0929867324666170713103621
Abstract: Background Glioblastoma is the most aggressive and deadly brain tumor, with low disease-free period even after surgery and combined radio and chemotherapies. Among the factors contributing to the devastating effect of this tumor in the… read more here.
Keywords: channel kca3; kca3; activated channel; ca2 activated ... See more keywords
Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing
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DOI: 10.3389/fcvm.2021.656631
Abstract: Aims: To investigate the role of KCa3. 1 inhibition in macrophage pro-inflammatory polarization and vulnerability to atrial fibrillation (AF) in a canine model with prolonged rapid atrial pacing. Materials and Methods: Twenty beagle dogs (weighing… read more here.
Keywords: group; kca3; model; macrophage ... See more keywords
Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.997621
Abstract: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation. Immune dysfunction is an essential mechanism in the pathogenesis of RA and directly linked to synovial inflammation and cartilage/bone destruction. Intermediate conductance Ca2+-activated… read more here.
Keywords: kca3; kca3 immune; rheumatoid arthritis; arthritis ... See more keywords