New Insights On KCA3.1 Channel Modulation.
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DOI: 10.2174/1381612826666200316152645
Abstract: The human intermediate conductance calcium activated potassium channel, KCa3.1, is involved in several pathophysiological conditions playing a critical role in cell secretory machinery and calcium signalling. The recent cryo-EM analysis opens new insights in the… read more here.
Keywords: modulation; kca3 channel; calcium; new insights ... See more keywords
KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
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DOI: 10.2174/1570159x15666170630164226
Abstract: Background The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells,… read more here.
Keywords: channel modulators; kca3 channel; compounds glioblastoma; therapeutic compounds ... See more keywords
Structure, Gating and Basic Functions of the Ca2+-activated K Channel of Intermediate Conductance
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DOI: 10.2174/1570159x15666170830122402
Abstract: Background The KCa3.1 channel is the intermediate-conductance member of the Ca2+-activated K channel superfamily. It is widely expressed in excitable and non-excitable cells, where it plays a major role in a number of cell functions.… read more here.
Keywords: kca3 channel; channel intermediate; intermediate conductance; ca2 ... See more keywords