Co‐staining of KCa3.1 Channels in NSCLC Cells with a Small‐Molecule Fluorescent Probe and Antibody‐Based Indirect Immunofluorescence
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DOI: 10.1002/cmdc.202000652
Abstract: The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was… read more here.
Keywords: indirect immunofluorescence; antibody; kca3; channel ... See more keywords
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small‐Molecule Fluorescent Probes
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DOI: 10.1002/cmdc.202200551
Abstract: The Ca2+ activated K+ channel KCa3.1 is overexpressed in several human tumor cell lines, e. g. clear cell renal carcinoma, prostate cancer, non‐small cell lung cancer. Highly aggressive cancer cells use this ion channel for key… read more here.
Keywords: imaging kca3; tumor cells; kca3; kca3 channels ... See more keywords
Muscle Damage in Dystrophic mdx Mice Is Influenced by the Activity of Ca2+-Activated KCa3.1 Channels
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DOI: 10.3390/life12040538
Abstract: Duchenne muscular dystrophy (DMD) is an X-linked disease, caused by a mutant dystrophin gene, leading to muscle membrane instability, followed by muscle inflammation, infiltration of pro-inflammatory macrophages and fibrosis. The calcium-activated potassium channel type 3.1… read more here.
Keywords: damage; mdx; muscle; kca3 channels ... See more keywords