KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.06.001
Abstract: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually assumed to contribute to abnormal… read more here.
Keywords: regulates neuronal; neuronal excitability; kcc2 regulates; downregulation ... See more keywords
K-Cl Cotransporter 2–mediated Cl− Extrusion Determines Developmental Stage–dependent Impact of Propofol Anesthesia on Dendritic Spines
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001587
Abstract: Background: General anesthetics potentiating &ggr;-aminobutyric acid (GABA)–mediated signaling are known to induce a persistent decrement in excitatory synapse number in the cerebral cortex when applied during early postnatal development, while an opposite action is produced… read more here.
Keywords: propofol; cotransporter mediated; mediated inhibition; gabaa mediated ... See more keywords
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau0164
Abstract: KCC2 expression–enhancing small molecules rescue cellular and behavior deficits in human RTT neurons and Mecp2 mutant mice. Restoring balance in Rett syndrome Rett syndrome (RTT) is a neurodevelopmental disorder causing cognitive, motor, and emotional impairments.… read more here.
Keywords: rtt; rett syndrome; expression; mecp2 mutant ... See more keywords
KCC2 Much Chloride Might Not Be the Only Problem
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Currents"
DOI: 10.1177/1535759719890333
Abstract: KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction With Task-3 Channels Goutierre M, Al Awabdh S, Donneger F, et al. Cell Rep. 2019;28(1):91-103.e7. doi:10.1016/j.celrep.2019.06.001. PMID: 31269453. KCC2 regulates neuronal transmembrane chloride gradients and thereby… read more here.
Keywords: gaba signaling; chloride; kcc2 much; kcc2 ... See more keywords
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069221082880
Abstract: GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K+-Cl--cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have focused on the additive… read more here.
Keywords: gaba; remifentanil induced; rih; kcc2 ... See more keywords
Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.912812
Abstract: KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders,… read more here.
Keywords: small molecule; kcc2 potentiation; kcc2 potentiators; molecule kcc2 ... See more keywords
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.826427
Abstract: K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors. During development, late… read more here.
Keywords: imbalance cortical; gabaergic neurons; loss kcc2; kcc2 ... See more keywords
Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1081657
Abstract: The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of… read more here.
Keywords: deletion; kcc2; chloride; memory ... See more keywords