Comprehensive Analysis of the Oncogenic, Genomic Alteration, and Immunological Landscape of Cation-Chloride Cotransporters in Pan-Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.819688
Abstract: Background Assessing the phenotypic diversity underlying tumor progression requires the identification of variations in the respective molecular interaction in the tumor microenvironment (TME). Despite emerging studies focusing on the association between cation-chloride cotransporters (CCCs) and… read more here.
Keywords: kcc2 nkcc1; cell; pan cancer; cancer patients ... See more keywords
Prenatal Hypoxia Induces Cl– Cotransporters KCC2 and NKCC1 Developmental Abnormality and Disturbs the Influence of GABAA and Glycine Receptors on Fictive Breathing in a Newborn Rat
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.786714
Abstract: Prenatal hypoxia is a recognised risk factor for neurodevelopmental disorders associated with both membrane proteins involved in neuron homeostasis, e.g., chloride (Cl–) cotransporters, and alterations in brain neurotransmitter systems, e.g., catecholamines, dopamine, and GABA. Our… read more here.
Keywords: prenatal hypoxia; glycine receptors; kcc2 nkcc1; fictive breathing ... See more keywords
Beta-Amyloid (Aβ1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus
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DOI: 10.3390/molecules27082440
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief. Recent evidence suggests the γ-aminobutyric acid (GABA) neurotransmitter system undergoes remodeling in… read more here.
Keywords: nkcc1 expression; mouse hippocampal; expression levels; expression ... See more keywords
Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031344
Abstract: Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale. Current therapies offer a… read more here.
Keywords: cation chloride; chloride cotransporters; cotransporters kcc2; neuropsychiatric disorders ... See more keywords