CRISPR-based KCC2 upregulation attenuates drug-resistant seizure in mouse models of epilepsy.
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DOI: 10.1002/ana.26656
Abstract: OBJECTIVE Precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive. METHODS Here, we employed a CRISPRa system delivered by adeno-associated viruses (AAV) to specifically upregulate KCC2 in… read more here.
Keywords: epilepsy; kcc2 upregulation; seizure; drug resistant ... See more keywords