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   Articles with "kcne1" as a keyword



Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.01.030

Abstract: Background Recent studies have revealed that mutation in KCNE1, &bgr;‐subunits of cardiac potassium channel, involved in ventricular fibrillation. Whereas its role in early repolarization syndrome (ERS) is less well understood. Objective To study whether mutant… read more here.

Keywords: kcne1 associated; mutation kcne1; early repolarization; kcne1 ... See more keywords

Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.ade7109

Abstract: Estradiol (17$β$-E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syndrome (LQTS) compared to men. However, the underlying mechanisms remain poorly understood, and little is known about the impact of… read more here.

Keywords: associated mutations; lqts associated; kcne1; mutations kcne1 ... See more keywords

A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15121550

Abstract: Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit… read more here.

Keywords: iks; long syndrome; kcne1; kcne1 variants ... See more keywords

KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site

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recommendations! Published in 2018 at "eLife"

DOI: 10.7554/elife.37257

Abstract: The voltage-gated potassium channel KV7.1 and the auxiliary subunit KCNE1 together form the cardiac IKs channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate KV7.1… read more here.

Keywords: polyunsaturated fatty; binding site; fatty acids; kv7 ... See more keywords