Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.10907
Abstract: Aldosterone-producing adenomas (APAs) harbor marked intratumoral heterogeneity in terms of morphology, steroidogenesis, and genetics. However, an association of biological significance of morphologically identified tumor cell subtypes and genotypes is virtually unknown. KCNJ5 mutation is most… read more here.
Keywords: kcnj5; aldosterone producing; mutated apas; kcnj5 mutated ... See more keywords
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0282
Abstract: Somatic mutation in the KCNJ5 gene is a common driver of autonomous aldosterone overproduction in aldosterone-producing adenomas (APA). KCNJ5 mutations contribute to a loss of potassium selectivity and an inward Na+ current could be detected… read more here.
Keywords: kcnj5; mutated kcnj5; kcnj5 gene; kcnj5 mutations ... See more keywords