KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma
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DOI: 10.1097/hjh.0000000000001578
Abstract: Objective: To investigate the effect of KCNJ5 mutations on the cure of hypertension in patients with aldosterone-producing adenoma (APA) after unilateral adrenalectomy. Methods: Our study included 142 patients with APA, who were detected with an… read more here.
Keywords: aldosterone producing; kcnj5 mutations; resolution hypertension; hypertension ... See more keywords
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
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DOI: 10.1530/jme-20-0282
Abstract: Somatic mutation in the KCNJ5 gene is a common driver of autonomous aldosterone overproduction in aldosterone-producing adenomas (APA). KCNJ5 mutations contribute to a loss of potassium selectivity and an inward Na+ current could be detected… read more here.
Keywords: kcnj5; mutated kcnj5; kcnj5 gene; kcnj5 mutations ... See more keywords
Primary aldosteronism diagnostics: KCNJ5 mutations and hybrid steroid synthesis in aldosterone-producing adenomas.
Sign Up to like & getrecommendations! Published in 2020 at "Gland surgery"
DOI: 10.21037/gs.2019.10.22
Abstract: Primary aldosteronism (PA) is characterized by autonomous aldosterone production by renin-independent mechanisms and is most commonly sporadic. While 60-70% of sporadic PA can be attributed to bilateral hyperaldosteronism, the remaining 30-40% is caused by a… read more here.
Keywords: aldosterone; primary aldosteronism; aldosteronism diagnostics; aldosterone producing ... See more keywords