KCNQ1 is internalized by activation of α1 adrenergic receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113628
Abstract: KCNQ1 (Kv7.1 or KvLQT1) plays important physiological roles in various tissues forming potassium channels with KCNE subunits. Among the channels formed by KCNQ1 and KCNE subunits, the best studied is the slow delayed rectifier potassium… read more here.
Keywords: kcnq1; activation adrenergic; internalization; kcnq1 kcne1 ... See more keywords
shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23074053
Abstract: Long-QT syndrome type 1 (LQT1) is caused by mutations in KCNQ1. Patients heterozygous for such a mutation co-assemble both mutant and wild-type KCNQ1-encoded subunits into tetrameric Kv7.1 potassium channels. Here, we investigated whether allele-specific inhibition… read more here.
Keywords: kcnq1; disease; targeting common; allele ... See more keywords
Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants
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DOI: 10.3390/ijms24021350
Abstract: The KCNQ1 gene encodes the α-subunit of the cardiac voltage-gated potassium (Kv) channel KCNQ1, also denoted as Kv7.1 or KvLQT1. The channel assembles with the ß-subunit KCNE1, also known as minK, to generate the slowly… read more here.
Keywords: kcnq1; kcnq1 variants; romano ward; ward syndrome ... See more keywords
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48576
Abstract: Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form IKs channels… read more here.
Keywords: vsd pore; pore coupling; state; vsd ... See more keywords