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   Articles with "kcnq2" as a keyword



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Role of KCNQ2 channels in orofacial cold sensitivity: KCNQ2 upregulation in trigeminal ganglion neurons after infraorbital nerve chronic constrictive injury

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recommendations! Published in 2018 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.11.026

Abstract: Sensitivity to cooling temperatures often becomes heightened in orofacial regions leading to orofacial cold allodynia/hyperalgesia after chronic trigeminal nerve injury. KCNQ2 channels are involved in controlling excitability of primary afferent neurons and thereby regulate sensory… read more here.

Keywords: orofacial cold; sensitivity; kcnq2 channels; kcnq2 ... See more keywords
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Hyperexcitable arousal circuits drive sleep instability during aging

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recommendations! Published in 2022 at "Science"

DOI: 10.1126/science.abh3021

Abstract: Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more frequent neuronal activity epochs driving… read more here.

Keywords: kcnq2; sleep fragmentation; hcrt; hcrt neurons ... See more keywords
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Genetic inhibition of KV7/M-channels increases the excitability of bronchopulmonary vagal nociceptive nerves

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5732751

Abstract: The KV7/M-channel, encoded by Kcnq2-5 genes, generates a “braking” potassium current (IM) and contributes to the regulation of neuronal excitability. We have previously reported that the vagal sensory nerves terminated in the mouse lungs expressed… read more here.

Keywords: kv7; nodose neurons; kcnq2; physiology ... See more keywords
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Heterozygous Deletion of Epilepsy Gene KCNQ2 Has Negligible Effects on Learning and Memory

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recommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"

DOI: 10.3389/fnbeh.2022.930216

Abstract: Neuronal Kv7/Potassium Voltage-Gated Channel Subfamily Q (KCNQ) potassium channels underlie M-current that potently suppresses repetitive and burst firing of action potentials (APs). They are mostly heterotetramers of Kv7.2 and Kv7.3 subunits in the hippocampus and… read more here.

Keywords: kcnq2; effects learning; mice; memory ... See more keywords
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Clinical Study of 30 Novel KCNQ2 Variants/Deletions in KCNQ2-Related Disorders

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recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.809810

Abstract: Background KCNQ2-related disorder is typically characterized as neonatal onset seizure and epileptic encephalopathy. The relationship between its phenotype and genotype is still elusive. This study aims to provide clinical features, management, and prognosis of patients… read more here.

Keywords: patients novel; kcnq2 related; novel kcnq2; kcnq2 ... See more keywords
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Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21124447

Abstract: Complex neurodevelopmental syndromes frequently have an unknown etiology, in which genetic factors play a pathogenic role. This study utilizes whole-exome sequencing (WES) to examine four members of a family with a son presenting, since birth,… read more here.

Keywords: duplication; frame duplication; delay; novel dominant ... See more keywords
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Bone Mineral Density and Body Composition in Males with Motor Neuron Disease: A Study from Teaching Hospital in Southern Part of India

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recommendations! Published in 2022 at "Annals of Indian Academy of Neurology"

DOI: 10.4103/aian.aian_386_21

Abstract: 1. Spagnoli C, Salerno GG, Iodice A, Frattini D, Pisani F, Fusco C. KCNQ2 encephalopathy: A case due to a de novo deletion. Brain Dev 2018;40:65‐8. 2. Pisano T, Numis AL, Heavin SB, Weckhuysen S,… read more here.

Keywords: mineral density; kcnq2 encephalopathy; body composition; kcnq2 ... See more keywords