Role of KCNQ2 channels in orofacial cold sensitivity: KCNQ2 upregulation in trigeminal ganglion neurons after infraorbital nerve chronic constrictive injury
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.026
Abstract: Sensitivity to cooling temperatures often becomes heightened in orofacial regions leading to orofacial cold allodynia/hyperalgesia after chronic trigeminal nerve injury. KCNQ2 channels are involved in controlling excitability of primary afferent neurons and thereby regulate sensory… read more here.
Keywords: orofacial cold; sensitivity; kcnq2 channels; kcnq2 ... See more keywords
Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.19.476944
Abstract: Neuronal KCNQ channels mediate the muscarine-regulated M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However, the impact that… read more here.
Keywords: mechanisms epilepsy; movement; kcnq2 channels; voltage ... See more keywords
The Voltage-Sensor S4 Rises to the Occasion in KCNQ2 Channel Activation
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221132972
Abstract: Distinctive Mechanisms of Epilepsy-Causing Mutants Discovered by Measuring S4 Movement in KCNQ2 Channels Edmond MA, Hinojo-Perez A, Wu X, Perez Rodriguez ME, Barro-Soria R. Elife. 2022;11:e77030. doi:10.7554/eLife.77030 Neuronal KCNQ channels mediate the M-current, a key… read more here.
Keywords: kcnq2 channel; kcnq2 channels; voltage; voltage sensor ... See more keywords
KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathic pain in diabetic rats
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DOI: 10.1177/1744806918793229
Abstract: Background Diabetic neuropathic pain is poorly controlled by analgesics, and the precise molecular mechanisms underlying hyperalgesia remain unclear. The KCNQ2/3/5 channels expressed in dorsal root ganglion neurons are important in pain transmission. The expression and… read more here.
Keywords: ganglion neurons; root ganglion; kcnq2 channels; dorsal root ... See more keywords